Why This $40B CIO Prefers the iShares Global 100 ETF (IOO) Over the S&P 500 (2026)

In a world where investment strategies are constantly evolving, it's intriguing to uncover lesser-known gems that offer a unique perspective on the market. Today, we delve into the insights of Will McGough, a CIO with a $40 billion portfolio, who has identified an ETF that challenges the traditional benchmarks.

Beyond the S&P 500: A Global Perspective

The S&P 500 has long been the go-to index for investors seeking broad exposure to large-cap US stocks. However, McGough argues that this benchmark may be limiting, as it fails to capture the global nature of today's economy, especially in the AI sector.

The S&P Global 100: A More Comprehensive Approach

McGough proposes the S&P Global 100 as a more holistic index, tracking a diverse selection of around 100 top stocks worldwide by market cap. This index, and its corresponding ETF, the iShares Global 100 ETF (IOO), offers exposure to key international players in the AI space, such as Samsung Electronics, ASML, and SAP.

What makes this particularly fascinating is the diverse range of industries represented within the fund. From memory chip makers to software giants and energy firms, it showcases the interconnected nature of the global economy and the importance of a diversified approach.

Blurring Regional Boundaries

McGough highlights how the traditional regional classifications for stocks are becoming less relevant, especially for companies tied to the AI boom. He believes that investing in the IOO ETF allows investors to cut through these predetermined definitions and focus on the dominant, large-cap companies with strong growth potential.

Personally, I find this shift in perspective intriguing. It challenges the conventional wisdom of regional investing and forces us to reconsider our strategies in a rapidly globalizing world.

The AI Trade: A Growing Theme

One of the key advantages of the IOO ETF is its exposure to the AI trade. With a significant weighting towards tech stocks, including Nvidia, Apple, and Alphabet, the fund captures the growth potential of this sector.

However, a concern arises with such a heavy tilt towards tech. McGough argues that the AI trade still has momentum, citing rising capex and the ongoing data center buildout. He believes we're only in the early stages of this trend, which implies continued growth potential.

This raises a deeper question: Are we underestimating the impact of AI on the global economy? If so, investing in funds like IOO could be a strategic move to capture this growth.

A Smaller, Yet Powerful Fund

With around $8 billion in assets under management, the IOO ETF is significantly smaller than its S&P 500 counterparts. However, its low annual expense ratio of 0.04% makes it an attractive option for investors seeking global exposure without the high fees.

While it may not include every notable AI player, such as Taiwan Semiconductor, the fund's top holdings showcase a diverse range of companies at the forefront of this technological revolution.

Final Thoughts

The insights provided by Will McGough offer a fresh perspective on global investing. By challenging traditional benchmarks and embracing a more holistic approach, investors can gain exposure to the dynamic and interconnected nature of today's economy.

As we navigate the ever-changing investment landscape, it's essential to keep an open mind and consider alternative strategies. The IOO ETF serves as a reminder that sometimes, the lesser-known paths can lead to valuable discoveries.

Why This $40B CIO Prefers the iShares Global 100 ETF (IOO) Over the S&P 500 (2026)

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